Alpha-1+Antitrypsin-Yarit+O.

Yarit Osorio Alpha-1 Antitrypsin **Description: **Alpha-1 damages the lungs alveoli. This can make the person harder to breathe. Therefore can cause them to cough and get a inhaler. Moreover, it is caused by mutations in the serpina gene on chromosome. So Appha-1 is produced in the liver and released into the blood.

**I ****nheritance: **It is a recessive disorder. An offspring well only get it when both parents have the disease. However, if one of the parents is healthy the offspring well become a carrier.
 * Punnett Square: **



**Pedigree Chart: ** 

**Symptoms: **Damages the tiny air sacs in the lungs. When the alveoli are damaged, the lungs aren’t able to expand and can cause a person not to breathe normally

**Diagnosis: **It is misdiagnosed because its symptoms look a lot like the symptoms of asthma, bronchitis, or smoking induced emphysema.

**Treatment: **Doctors try to increase the amount of alpha-1 antitryin in a patients blood with augmentation therapy. To control bronchial symptoms, doctors prescribe inhaler such as inhaled steroids or bronchodilators. Patients in the late stages of the disease may have so much longer liver damage that they need an organ transplant.

**<span style="color: black; font-family: 'Times','serif'; font-size: 16px;">Interesting Facts: **
 * 1) <span style="color: black; font-family: 'Times','serif'; font-size: 16px; line-height: 115%;">Alpa-1 protects the lungs from neutrophil elastase
 * 2) <span style="color: black; font-family: 'Times','serif'; font-size: 16px; line-height: 115%;">Alpha-1 is more prevalent among Caucasians
 * 3) <span style="color: black; font-family: 'Times','serif'; font-size: 16px; line-height: 115%;">Washing your hands is an effective way to avoid contracting or spreading this disease
 * 4) <span style="color: black; font-family: 'Times','serif'; font-size: 16px; line-height: 115%;">People with this Disease must stay away from drugs like tobacco and smoking


 * <span style="color: black; font-family: 'Times','serif'; font-size: 16px; line-height: 115%;">Support Groups: **<span style="color: black; font-family: 'Times','serif'; font-size: 16px; line-height: 115%;">Alpha-1 Association
 * <span style="color: black; font-family: 'Times','serif'; font-size: 16px; line-height: 115%;">Sources: **<span style="color: black; font-family: 'Arial','sans-serif'; font-size: 13px; line-height: 115%;">http://learn.genetics.utah.edu/content/disorders/whataregd/a1ad/index.html


 * <span style="color: black; font-family: 'Times','serif'; font-size: 16px; line-height: 115%;">Pictures: **

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